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KMID : 0370219840280050249
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Yakhak Hoeji
1984 Volume.28 No. 5 p.249 ~ p.256
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Pharmacological Studies on the Antihypertensive Effects of Cinnarizine Coadministered with Propranolol or Metoprolol(I). Effects on Blood Pressure Change
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허인회/Huh IH
안형수/Ann HS
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Abstract
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The effects of Ca2+-antagonist, cinnarizine, on the antihypertensive effects of propranolol and metoprolol were investigated in normal cat (i.v.) and SHR (p.o.). Cinnarizine increased the antihypertensive effect of propranolol, but not of metoprolol. It inhibited the heart rate decreasing effects of propranolol and metoprolol slightly. It decreased the norepinephrine-induced blood pressure increasing effect and isoproterenol-induced blood pressure decreasing effect when coadministered with metoprolol orally for 4 weeks in SHRs.
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